Disease Prevention Science Course Research
Tokyo Medical and Dental University, Medical Research Institute, Molecular Epidemiology Department (Professor Masaaki Muramatsu, Associate Professor Noriko Sato)
(1) The relationships between genetic and environmental factors in metabolic syndrome, arteriosclerosis, etc.
(2) Basic research for preemptive medicine that spans generations
Q: What kinds of research are you actually doing?
(1) Using anonymized genome DNA, we are performing the typing of genetic polymorphism. Using genetic information produced by the typing and clinical information (including nutrition information and life habit information such as physical activity level), we analyze disease-related genetic polymorphism and relationships with environmental factors. In addition, using open data on the human genome, we extract information actually needed for healthcare and personalized preventive medicine, and we engage in applied research aimed at making that information useful.
(2) It is known that a susceptibility to lifestyle-related illnesses is influenced by environmental factors existing before birth. With this in mind, in joint research with Medical Hospital, Tokyo Medical and Dental University, we are now preparing to examine the impact of perinatal period risks on the epigenome and future health of the fetus. At the same time, in experiments using mice, we are analyzing the impact that gestation period environmental factors have on the epigenome condition of blood stem (precursor) cells.
Q: What specific things can students learn in your laboratory?
Through initiatives for discovering meaningful knowledge in personal genome information, students can learn extrapolation methods, methods for making rational explanations, and methods for making presentations to communicate with others. In addition, the acquisition of knowledge concerning the genome and epigenome will help students develop the ability to think in a more scientific way about relationships between the body and illness.
Q: In what kinds of fields are students who have studied in your laboratory active?
We do have people doing postdoctoral research, but there are also many graduates who find jobs at companies. They are working in a variety of fields, including manufacturers, CRO, computer-related companies, etc.
Q: Are graduate students who are working adults able to study here?
We accept such people. It is fine as long as they are dedicated and can attend at least once on a weekday as well as on the weekend.
Q：Location of your lab?
The Molecular Epidemiology Department is on the Surugadai Campus of Tokyo Medical and Dental University.
Q: What is the atmosphere like in the Molecular Epidemiology Department?
The Molecular Epidemiology Department’s associate professor and assistant professor are women, and more than half of the students are exchange students from abroad. This diverse group enjoys animated discussions as it engages in study and research from day to day. Department conferences are held in English, giving them a kind of “overseas study” atmosphere.
Q: Please say a word to students who want to enroll./strong>
We are approaching a “personal genome” era in which people will decode their own genes and apply the resulting information to healthcare. There are many problems that must be faced so why not combine your wisdom with ours to help pioneer the new era.
For details concerning this laboratory see here